Genetics meets environment: evaluating gene-environment interactions in neurologic diseases.
Identifieur interne : 001659 ( Main/Exploration ); précédent : 001658; suivant : 001660Genetics meets environment: evaluating gene-environment interactions in neurologic diseases.
Auteurs : Connie Marras [Canada] ; Samuel M. GoldmanSource :
- Seminars in neurology [ 1098-9021 ] ; 2011.
English descriptors
- KwdEn :
- MESH :
Abstract
The vast majority of disease is due to complex relationships between genetic and environmental factors. Single genetic or environmental causes are rare. Unfortunately, this presents major challenges for assessing disease risk in individuals. Further complicating the situation is the fact that there are many ways in which genetic and environmental determinants can combine to cause disease. This review explores the concepts of gene-environment interaction to provide a basic understanding of the principles of interactions and approaches to studying them. Collaborations between genetics and environmental experts will be crucial to understand the complex relationships.
DOI: 10.1055/s-0031-1299793
PubMed: 22266892
Affiliations:
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Le document en format XML
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Goldman</name></author></analytic><series><title level="j">Seminars in neurology</title><idno type="eISSN">1098-9021</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Environment</term><term>Gene-Environment Interaction</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Multiple Sclerosis (etiology)</term><term>Multiple Sclerosis (genetics)</term><term>Nervous System Diseases (etiology)</term><term>Nervous System Diseases (genetics)</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (genetics)</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Multiple Sclerosis</term><term>Nervous System Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Multiple Sclerosis</term><term>Nervous System Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Environment</term><term>Gene-Environment Interaction</term><term>Genetic Predisposition to Disease</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The vast majority of disease is due to complex relationships between genetic and environmental factors. Single genetic or environmental causes are rare. Unfortunately, this presents major challenges for assessing disease risk in individuals. Further complicating the situation is the fact that there are many ways in which genetic and environmental determinants can combine to cause disease. This review explores the concepts of gene-environment interaction to provide a basic understanding of the principles of interactions and approaches to studying them. Collaborations between genetics and environmental experts will be crucial to understand the complex relationships.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel M" last="Goldman">Samuel M. Goldman</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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